Role and mechanism of ferroptosis in acute lung injury

Cell Cycle. 2023 Oct;22(19):2119-2129. doi: 10.1080/15384101.2023.2278328. Epub 2023 Dec 5.

Abstract

Ferroptosis is a new non-apoptotic cell death caused by the accumulation of dysregulated metabolism of ferric iron, amino acids or lipid peroxidation. Increasing studies suggest that ferroptosis is involved in the acute lung injury (ALI). This article aims to review the role of ferroptosis in ALI. ALI is a common respiratory disease and presents a high mortality rate. Inhibiting cell ferroptosis of lung improves the ALI. In addition, several signaling pathways are related to ferroptosis in ALI, involving in iron homeostasis, lipid peroxidation, and amino acid metabolism. Moreover, there are various key factors to regulate the occurrence of ferroptosis in ALI, such as ACSL4, NRF2, and P53. The ACSL4 promotes the ferroptosis, while the NRF2 alleviates the ferroptosis in ALI. The main effect of P53 is to promote ferroptosis. Accordingly, ferroptosis is involved in ALI and may be an important therapeutic target for ALI.

Keywords: Ferroptosis; acute lung injury; lipid peroxidation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Lung Injury*
  • Ferroptosis*
  • Humans
  • Iron
  • NF-E2-Related Factor 2 / genetics
  • Tumor Suppressor Protein p53

Substances

  • NF-E2-Related Factor 2
  • Tumor Suppressor Protein p53
  • Iron

Grants and funding

This article was supported by the National Natural Science Foundation of China (grant no. 82160007), the Yunnan Provincial Science and Technology Department [grant no. 2019FE001 (-058)], and Teaching and Reform Program of Kunming Medical University (NO. 2021-JY-Y-051).