The mitochondrial respiratory chain

Mårten Wikström; Cristina Pecorilla; Vivek Sharma

doi:10.1016/bs.enz.2023.05.001

The mitochondrial respiratory chain

Enzymes. 2023:54:15-36. doi: 10.1016/bs.enz.2023.05.001. Epub 2023 May 26.

Authors

Mårten Wikström¹, Cristina Pecorilla², Vivek Sharma³

Affiliations

¹ HiLife Institute of Biotechnology, University of Helsinki, Biocenter, Viikinkaari, Helsinki, Finland. Electronic address: marten.wikstrom@helsinki.fi.
² Department of Physics, University of Helsinki, Gustaf Hällströmin katu, Helsinki, Finland.
³ HiLife Institute of Biotechnology, University of Helsinki, Biocenter, Viikinkaari, Helsinki, Finland; Department of Physics, University of Helsinki, Gustaf Hällströmin katu, Helsinki, Finland.

PMID: 37945170
DOI: 10.1016/bs.enz.2023.05.001

Abstract

We present a brief review of the mitochondrial respiratory chain with emphasis on complexes I, III and IV, which contribute to the generation of protonmotive force across the inner mitochondrial membrane, and drive the synthesis of ATP by the process called oxidative phosphorylation. The basic structural and functional details of these complexes are discussed. In addition, we briefly review the information on the so-called supercomplexes, aggregates of complexes I-IV, and summarize basic physiological aspects of cell respiration.

Keywords: Bioenergetics; Cell respiration; Cytochromes; Electron transfer; Oxidative phosphorylation; Oxygen consumption; Proton pumping; Proton transfer; Protonmotive force; Supercomplexes.

MeSH terms

Cell Respiration* / physiology
Electron Transport
Mitochondrial Membranes*
Oxidative Phosphorylation