MYC function and regulation in physiological perspective

Rajiv Kumar Jha; Fedor Kouzine; David Levens

doi:10.3389/fcell.2023.1268275

MYC function and regulation in physiological perspective

Front Cell Dev Biol. 2023 Oct 24:11:1268275. doi: 10.3389/fcell.2023.1268275. eCollection 2023.

Authors

Rajiv Kumar Jha¹, Fedor Kouzine¹, David Levens¹

Affiliation

¹ Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States.

Abstract

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression. MYC levels are tightly regulated, and deregulation of MYC has been associated with numerous diseases including cancer. Understanding the comprehensive biology of MYC under physiological conditions is an utmost necessity to demark biological functions of MYC from its pathological functions. Here we review the recent advances in biological mechanisms, functions, and regulation of MYC. We also emphasize the role of MYC as a global transcription amplifier.

Keywords: DNA-topology; MYC; MYC function; MYC regulation; MYC-inhibitors; transcription; transcription-amplifier.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. We have been supported by the Intramural Research Program of the US National Institutes of Health, National Cancer Institute, Center for Cancer Research.