Molecular mechanisms of uterine incision healing and scar formation

Eur J Med Res. 2023 Nov 8;28(1):496. doi: 10.1186/s40001-023-01485-w.

Abstract

Wound healing is a tandem process involving inflammation, proliferation, and remodeling, through which damage is repaired and ultimately scar tissue is formed. This process mainly relies on the complex and extensive interaction of growth factors and cytokines, which coordinate the synthesis of various cell types. The loss of normal regulation in any part of this process can lead to excessive scarring or unhealed wounds. Recent studies have shown that it is possible to improve wound healing and even achieve scar-free wound healing through proper regulation of cytokines and molecules in this process. In recent years, many studies have focused on accelerating wound healing and reducing scar size by regulating the molecular mechanisms related to wound healing and scar formation. We summarized the role of these factors in wound healing and scar formation, to provide a new idea for clinical scar-free healing treatment of uterine incisions.

Keywords: Caesarean delivery; Molecular mechanism; Scar; Uterus; Wound healing.

Publication types

  • Review

MeSH terms

  • Cicatrix* / pathology
  • Cicatrix* / therapy
  • Cytokines
  • Humans
  • Wound Healing* / physiology

Substances

  • Cytokines