CD-MOFs: From preparation to drug delivery and therapeutic application

Yanxue Si; Huize Luo; Pai Zhang; Chunliang Zhang; Juanjuan Li; Peng Jiang; Wenbing Yuan; Ruitao Cha

doi:10.1016/j.carbpol.2023.121424

CD-MOFs: From preparation to drug delivery and therapeutic application

Carbohydr Polym. 2024 Jan 1:323:121424. doi: 10.1016/j.carbpol.2023.121424. Epub 2023 Sep 20.

Authors

Yanxue Si¹, Huize Luo², Pai Zhang³, Chunliang Zhang⁴, Juanjuan Li⁵, Peng Jiang⁶, Wenbing Yuan⁷, Ruitao Cha⁸

Affiliations

¹ Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, PR China. Electronic address: siyx2020@nanoctr.cn.
² Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China. Electronic address: hzluo@email.cugb.edu.cn.
³ Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, PR China. Electronic address: zhangp2019@nanoctr.cn.
⁴ Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, PR China. Electronic address: zhangchl@nanoctr.cn.
⁵ School of Life Sciences, Hainan University, Haikou 570228, Hainan, PR China. Electronic address: lijuanjuan@hainanu.edu.cn.
⁶ CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Haidian District, Beijing 100190, P. R. China; College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: pjiang@nanoctr.cn.
⁷ School of Environmental and Chemical Engineering, Foshan University, Foshan 528000, PR China. Electronic address: hnyuanwb@126.com.
⁸ Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, 2 Tiantan Xi Li, Beijing 100050, PR China. Electronic address: chart@nanoctr.cn.

PMID: 37940296
DOI: 10.1016/j.carbpol.2023.121424

Abstract

Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of edibility, degradability, low toxicity, and high drug loading, which have attracted enormous interest, especially in drug delivery. This review summarizes the typical synthesis approaches of CD-MOFs, the drug loading methods, and the mechanism of encapsulation and release. The influence of the structure of CD-MOFs on their drug encapsulation and release is highlighted. Finally, the challenges CD-MOFs face are discussed regarding biosafety assessment systems, stability in aqueous solution, and metal ion effect.

Keywords: Cyclodextrin metal organic frameworks; Drug encapsulation; Drug release; Synthesis approaches; Therapeutic application.

Publication types

Review

MeSH terms

Cyclodextrins* / chemistry
Drug Delivery Systems
Metal-Organic Frameworks* / chemistry
Metals / chemistry
Water

Substances

Cyclodextrins
Metal-Organic Frameworks
Metals
Water