Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis

Ya-Jie Hu; Qian Lan; Bao-Jun Su; Yan Wang; Dong Liang

doi:10.1016/j.fitote.2023.105740

Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis

Fitoterapia. 2024 Jan:172:105740. doi: 10.1016/j.fitote.2023.105740. Epub 2023 Nov 7.

Authors

Ya-Jie Hu¹, Qian Lan¹, Bao-Jun Su¹, Yan Wang², Dong Liang³

Affiliations

¹ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: wy198565@163.com.
³ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Electronic address: liangdonggxnu@163.com.

PMID: 37939734
DOI: 10.1016/j.fitote.2023.105740

Abstract

Three new phenolic glycosides (1-3) and a new lignan glycoside (4), together with five known compounds (5-9) were isolated from the ethanol extract of the aerial part of Gaultheria leucocarpa var. yunnanensis (Franch.) T.Z.Hsu & R.C.Fang. Their structures were determined on the basis of spectroscopic techniques, experimental and calculated ECD spectra, acid hydrolysis, and enzymatic hydrolysis experiments. All the isolates were evaluated for their anti-inflammatory and antioxidant activities. Compounds 7 and 8 exhibited inhibitory effects against the LPS-induced production of NO with IC₅₀ of 63.71 and 10.66 μM, respectively, compared to L-NMMA having an IC₅₀ of 6.95 μM. Besides, compound 7 also represented significant DPPH radical scavenging activity with EC₅₀ of 18.75 μM, comparable with vitamin C (EC₅₀ = 15.77 μM).

Keywords: Anti-inflammatory; Antioxidant; Gaultheria leucocarpa var. yunnanensis; Lignan glycoside; Phenolic glycoside.

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Cardiac Glycosides*
Gaultheria* / chemistry
Glycosides / chemistry
Lignans* / pharmacology
Molecular Structure

Substances

Glycosides
Lignans
Anti-Inflammatory Agents
Cardiac Glycosides