2-Pyridone Formation: An Efficient Method for the Solid-Phase Synthesis of Homodimers

Abstract

This study presents an efficient method for on-resin dimer generation through self-condensation of 3,3-dimethoxypropionic acid-modified molecules, resulting in 2-pyridones. The approach demonstrated remarkable versatility by producing homodimers of peptides, peptoids, and non-peptidic ligands. Its ease of application, broad utility, and mild reaction conditions not only hold significance for peptide and peptoid research but also offer potential for the on-resin development of a wide range of bivalent ligands.

Keywords: Homodimer; Pyridone; Solid-phase synthesis; peptide.