Although MXene materials are considered an emerging research topic, they are receiving considerable interest because, like metals and graphene, they are good electronic conductors but with the particularity that they have a marked hydrophilic character. Having a structural organization and properties close to those of clay minerals (natural silicates typically with a lamellar morphology), they are sometimes referred to as "conducting clays" and exhibit colloidal, surface and intercalation properties also similar to those of clay minerals. The present contribution aims to inform and discuss the nature of MXenes in comparison with clay phyllosilicates, taking into account their structural analogies, outstanding surface properties and advanced applications. The current in-depth understanding of clay minerals may represent a basis for the future development of MXene-derived nanoarchitectures. Comparative examples of the preparation, and studies on the properties and applications of various nanoarchitectures based on clays and MXenes have been included in the present work.