Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog

Haemin Lee; Sanggu Kim; Dohee Lee; Yeon Chae; Taesik Yun; Mhan-Pyo Yang; Byeong-Teck Kang; Soochong Kim; Hakhyun Kim

doi:10.3389/fvets.2023.1287335

Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog

Front Vet Sci. 2023 Oct 23:10:1287335. doi: 10.3389/fvets.2023.1287335. eCollection 2023.

Authors

Haemin Lee¹, Sanggu Kim², Dohee Lee¹, Yeon Chae¹, Taesik Yun¹, Mhan-Pyo Yang¹, Byeong-Teck Kang¹, Soochong Kim², Hakhyun Kim¹

Affiliations

¹ Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
² Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

Abstract

Long-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature. A 5-year-old intact female Maltese dog was referred to our hospital with chronic intermittent vomiting. The dog had been administered omeprazole (0.7-1.0 mg/kg PO q24 h) for the management of hydrocephalus for over 4 years; the omeprazole dose was increased to 10 mg/kg PO q24 h 8 months prior to presentation at referring hospital. Abdominal ultrasonography revealed marked thickening of the gastric wall with multi-lobulated, thickened folds. Subsequent endoscopy revealed marked polypoid lesions, and histological examination of the biopsy samples was consistent with the fundic gland polyps associated with proton-pump inhibitor use in humans. The lesions resolved after cessation of omeprazole, as assessed by ultrasonography. This report describes a case of fundic gland polyps following the long-term administration of omeprazole in a dog.

Keywords: canine; gastrin; gastropathy; proton-pump inhibitor; vomiting.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Basic Research Lab Program (2022R1A4A1025557) through the National Research Foundation (NRF) of Korea, funded by the Ministry of Science and ICT.