Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl-phen-yl)carbamo-yl]phenyl acetate

Reham A Mohamed-Ezzat; Benson M Kariuki; Aladdin M Srour

doi:10.1107/S2056989023008526

Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl-phen-yl)carbamo-yl]phenyl acetate

Acta Crystallogr E Crystallogr Commun. 2023 Oct 5;79(Pt 11):999-1002. doi: 10.1107/S2056989023008526. eCollection 2023 Nov 1.

Authors

Reham A Mohamed-Ezzat¹, Benson M Kariuki², Aladdin M Srour³

Affiliations

¹ Chemistry of Natural & Microbial Products Department, National Research Centre, Cairo, Egypt.
² School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10, 3AT, United Kingdom.
³ Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo, 12622, Egypt.

Abstract

2-[(4-Acetyl-phen-yl)carbamo-yl]phenyl acetate, C₁₇H₁₅NO₄, has been synthesized and structurally characterized. In the structure, N-H⋯O hydrogen-bonding inter-actions form chains of mol-ecules aligned along the [101] direction. The chains are linked by π-π and C-H⋯π inter-actions, forming a three dimensional network. The compound has been screened for in vitro anti-proliferative activity revealing considerable activity.

Keywords: NCI 60 cell line; anti-proliferative activity; aspirin derivative; crystal structure.