2-[4-(2-Chloro-benz-yl)-3-methyl-6-oxo-1,6-di-hydro-pyridazin-1-yl]- N-(4-fluoro-phen-yl)acetamide

IUCrdata. 2023 Oct 19;8(Pt 10):x230901. doi: 10.1107/S241431462300901X. eCollection 2023 Oct.

Abstract

The conformation of the title mol-ecule, C20H17ClFN3O2, is partly determined by an intra-molecular C-H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro-benzene ring and the acetamide group. The 2-chloro-benzyl group is rotationally disordered over two orientations in a 0.656 (2): 0.344 (2) ratio. In the crystal, a layered structure is formed by N-H⋯O, C-H⋯O and C-H⋯F hydrogen bonds plus slipped π-π stacking inter-actions.

Keywords: aryl­acetamide; crystal structure; hydrogen bond; pyridazine; π-stacking.

Grants and funding

JTM thanks Tulane University for support of the Tulane Crystallography Laboratory.