In vivo synergistic tumor therapies based on copper sulfide photothermal therapeutic nanoplatforms

Jingwen Ma; Na Li; Jingjian Wang; Zhe Liu; Yulong Han; Yun Zeng

doi:10.1002/EXP.20220161

In vivo synergistic tumor therapies based on copper sulfide photothermal therapeutic nanoplatforms

Exploration (Beijing). 2023 Jun 24;3(5):20220161. doi: 10.1002/EXP.20220161. eCollection 2023 Oct.

Authors

Jingwen Ma¹, Na Li¹, Jingjian Wang¹, Zhe Liu², Yulong Han³, Yun Zeng^{4

5}

Affiliations

¹ Radiology Department CT and MRI Room Ninth Hospital of Xi'an Ninth Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an Shaanxi Province P. R. China.
² Department of Pathology Ninth Hospital of Xi'an Ninth Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an Shaanxi Province P. R. China.
³ School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USA.
⁴ School of Life Science and Technology Xidian University and Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education Xi'an Shaanxi Province P. R. China.
⁵ International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi'an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information, School of Life Science and Technology Xidian University Xi'an Shaanxi Province P. R. China.

Abstract

Tumor cells may be eliminated by increasing their temperature. This is achieved via photothermal therapy (PTT) by penetrating the tumor tissue with near-infrared light and converting light energy into heat using photothermal agents. Copper sulfide nanoparticles (CuS NPs) are commonly used as PTAs in PTT. In this review, we aimed to discuss the synergism between tumor PTT with CuS NPs and other therapies such as chemotherapy, radiotherapy, dynamic therapies (photodynamic, chemodynamic, and sonodynamic therapy), immunotherapy, gene therapy, gas therapy, and magnetic hyperthermia. Furthermore, we summarized the results obtained with a combination of two treatments and at least two therapies, with PTT as one of the included therapies. Finally, we summarized the benefits and drawbacks of various therapeutic options and state of the art CuS-based PTT and provided future directions for such therapies.

Keywords: copper sulfide; photothermal therapy; synergistic therapy; tumor treatment.

Publication types

Review