Supramolecular nanomedicines based on host-guest interactions of cyclodextrins

Fan Tong; Yang Zhou; Yanyan Xu; Yuxiu Chen; Natalia Yudintceva; Maxim Shevtsov; Huile Gao

doi:10.1002/EXP.20210111

Supramolecular nanomedicines based on host-guest interactions of cyclodextrins

Exploration (Beijing). 2023 May 28;3(4):20210111. doi: 10.1002/EXP.20210111. eCollection 2023 Aug.

Authors

Fan Tong¹, Yang Zhou¹, Yanyan Xu¹, Yuxiu Chen¹, Natalia Yudintceva², Maxim Shevtsov², Huile Gao¹

Affiliations

¹ Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University Chengdu China.
² Institute of Cytology of the Russian Academy of Sciences (RAS) St. Petersburg Russia.

Abstract

In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability of hydrophobic drug guests. In this review, we generalized the unique properties of CDs, CD-related supramolecular nanocarriers, supramolecular controlled release systems, and targeting systems based on CDs, and introduced the paradigms of these nanomedicines. In addition, we also discussed the prospects and challenges of CD-based supramolecular nanomedicines to facilitate the development and clinical translation of these nanomedicines.

Keywords: cyclodextrins; host–guest interactions; supramolecular nanomedicines.

Publication types

Review