A computational analysis of transcranial magnetic stimulation in patients with cranial defects and skull plate implants

Minmin Wang; Li Zhang

doi:10.1016/j.neucli.2023.102916

A computational analysis of transcranial magnetic stimulation in patients with cranial defects and skull plate implants

Neurophysiol Clin. 2023 Dec;53(6):102916. doi: 10.1016/j.neucli.2023.102916. Epub 2023 Nov 4.

Authors

Minmin Wang¹, Li Zhang²

Affiliations

¹ Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, School of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China; Binjiang Institute of Zhejiang University, Hangzhou, China. Electronic address: minminwang@zju.edu.cn.
² Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

PMID: 37931508
DOI: 10.1016/j.neucli.2023.102916

Abstract

We utilized computational analysis to investigate the impact of skull defects and skull implants on the TMS-induced EF. Our findings revealed a noteworthy alteration in the induced EF when acute skull defects were present. When high-conductivity titanium plates were used, we observed a pronounced increase in the peak EF, accompanied by a shift in the induced EF from the center towards both ends of the implant. These findings underscore the importance of carefully considering skull defects and implant materials during TMS.

Keywords: Computational model; Cranial defects; Skull plates; Transcranial magnetic stimulation.

MeSH terms

Humans
Prostheses and Implants
Skull* / surgery
Transcranial Magnetic Stimulation*