Clinical applications of polygenic risk score for coronary artery disease through the life course

Akl C Fahed; Pradeep Natarajan

doi:10.1016/j.atherosclerosis.2023.117356

Clinical applications of polygenic risk score for coronary artery disease through the life course

Atherosclerosis. 2023 Dec:386:117356. doi: 10.1016/j.atherosclerosis.2023.117356. Epub 2023 Oct 18.

Authors

Akl C Fahed¹, Pradeep Natarajan²

Affiliations

¹ Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: pnatarajan@mgh.harvard.edu.

PMID: 37931336
PMCID: PMC10842813 (available on 2024-12-01)
DOI: 10.1016/j.atherosclerosis.2023.117356

Abstract

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, highlighting the limitations of current primary and secondary prevention frameworks. In this review, we detail how the polygenic risk score for CAD can improve our current preventive and treatment frameworks across three clinical applications that span the life course: (i) identification and treatment of people at increased risk early in the life course prior to the onset of clinical risk factors, (ii) improving the precision around risk estimation in middle age, and (ii) guiding treatment decisions and enabling more efficient clinical trials even after the onset of CAD. We end by summarizing the efforts needed as we head towards more widespread use of polygenic risk score for CAD in clinical practice.

Keywords: Cardiovascular prevention; Coronary artery disease; Genetics; Genomic medicine; Genomic risk prediction; Polygenic score.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Coronary Artery Disease* / genetics
Coronary Artery Disease* / therapy
Humans
Life Change Events
Middle Aged
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding