Field validation of different intervention modes for the potential transmission risk of schistosomiasis during post-transmission interruption phase

Jiaxin Feng; Zhaoyu Guo; Peijun Qian; Wenya Wang; Hehua Hu; Xia Zhang; JingBo Xue; Yinlong Li; Chunli Cao; Yuwan Hao; Shizhu Li

doi:10.1371/journal.pntd.0011739

Field validation of different intervention modes for the potential transmission risk of schistosomiasis during post-transmission interruption phase

PLoS Negl Trop Dis. 2023 Nov 6;17(11):e0011739. doi: 10.1371/journal.pntd.0011739. eCollection 2023 Nov.

Authors

Jiaxin Feng^{1

2}, Zhaoyu Guo¹, Peijun Qian¹, Wenya Wang¹, Hehua Hu³, Xia Zhang³, JingBo Xue¹, Yinlong Li¹, Chunli Cao¹, Yuwan Hao¹, Shizhu Li^{1

4}

Affiliations

¹ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, People's Republic of China.
² Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, China.
³ Jiangling Center for Disease Control and Prevention, Hubei province, People's Republic of China.
⁴ School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Abstract

Objective: Precision interventions have been proposed in transmission-interrupted areas to further reduce the potential transmission risk of schistosomiasis. This study aimed to evaluate the effects of different interventions modes for potential transmission risk control.

Methods: Three groups of schistosomiasis-endemic villages were selected in Jiangling county, Hubei province. After baseline surveys in 2020, three intervention models were employed in 2021 and 2022. In Model 1, Oncomelania hupensis snail control in key settings and an integrated strategy with an emphasis on the infectious sources managing was employed. In Model 2, an integrated health education-led strategy with an emphasis on infectious source management was employed. In Model 3, only the integrated strategy with an emphasis on infectious source management was employed. The effects of the different intervention models were examined with multiple indicators after 2 years of intervention using the entropy-weighted technique for order of preference by similarity to ideal solution (TOPSIS), rank-sum ratio (RSR) and fuzzy combination model of entropy-weighted TOPSIS and RSR.

Results: Entropy-weighted TOPSIS modeling showed that the Ci values of Model 2 were 0.4434, 0.2759, and 0.3069 in the three pilot villages, Ci values were larger, with top comprehensive ranking. The results of the RSR method showed that the RSR values of Model 2 were 0.75, 0.708, and 0.736 in the three pilot villages, with top comprehensive ranking. The results from the fuzzy combination model of entropy-weighted TOPSIS and RSR showed that implementation of Model 2 resulted in the highest comprehensive ranking among the three models in the three pilot villages under Ci: RSR = 0.1: 0.9, Ci: RSR = 0.5: 0.5 and Ci: RSR = 0.9: 0.1.

Conclusion: The integrated health education-led strategy with an emphasis on infectious source management was the optimal model to manage the risk of transmission of schistosomiasis during the post-transmission interruption phase.

Copyright: © 2023 Feng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

MeSH terms

Animals
China / epidemiology
Health Education
Humans
Schistosomiasis* / epidemiology
Schistosomiasis* / prevention & control
Snails
Surveys and Questionnaires

Grants and funding

This research was funded by the National Key Research and Development Program of China (No.2021YFC2300800)(SL,YH,JX,JF), (No.2021YFC2300803)(SL,YH,YL,JF,PQ); National Natural Science Foundation of China (No. 32161143036)(SL,YH,HH,JF,CC); International Joint Laboratory on Tropical Diseases Control in Greater Mekong Subregion (No. 21410750200)(SL,JX,JF,WW,YH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.