Significant increase in the prevalence of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, particularly the USA300 variant ΨUSA300, in the Japanese community

Hiroshi Kaneko; Miki Kanai; Takumi Saito; Yuka Yanagi; Hana Kobayashi; Rikuto Kurihara; Masami Ikeda; Osamu Nemoto; Naoko Baba; Yasushi Matsuzaki; Daisuke Sawamura; Fumiko Shimoe; Yoichi Inaba; Yoko Kobayashi; Satoru Kawasaki; Toru Ueki; Sakae Funatsu; Shigeho Shirahama; Misao Oba; Takaya Hasegawa; Hirotoshi Furukawa; Toshiko Miyata; Masaaki Isonokami; Shigeru Fujita; Hidemasa Nakaminami

doi:10.1128/spectrum.01248-23

Significant increase in the prevalence of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, particularly the USA300 variant ΨUSA300, in the Japanese community

Microbiol Spectr. 2023 Dec 12;11(6):e0124823. doi: 10.1128/spectrum.01248-23. Epub 2023 Nov 6.

Authors

Hiroshi Kaneko¹, Miki Kanai¹, Takumi Saito¹, Yuka Yanagi¹, Hana Kobayashi¹, Rikuto Kurihara¹, Masami Ikeda², Osamu Nemoto³, Naoko Baba⁴, Yasushi Matsuzaki⁵, Daisuke Sawamura⁵, Fumiko Shimoe⁶, Yoichi Inaba⁷, Yoko Kobayashi⁸, Satoru Kawasaki⁹, Toru Ueki¹⁰, Sakae Funatsu¹¹, Shigeho Shirahama¹², Misao Oba¹², Takaya Hasegawa¹³, Hirotoshi Furukawa¹⁴, Toshiko Miyata¹⁵, Masaaki Isonokami¹⁶, Shigeru Fujita¹⁷, Hidemasa Nakaminami¹

Affiliations

¹ Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , Tokyo, Japan.
² Department of Dermatology, Takamatsu Red Cross Hospital , Kagawa, Japan.
³ Sapporo Skin Clinic , Hokkaido, Japan.
⁴ Department of Dermatology, Kanagawa Children's Medical Center , Kanagawa, Japan.
⁵ Department of Dermatology, Hirosaki University Graduate School of Medicine , Aomori, Japan.
⁶ Shimoe Dermatology Clinic , Osaka, Japan.
⁷ Atopia Clinic , Kumamoto, Japan.
⁸ Kobayashi Dermatology Clinic , Tokyo, Japan.
⁹ Kawasaki Dermatology Clinic , Tokyo, Japan.
¹⁰ Ueki Dermatology Plastic Surgery , Tokyo, Japan.
¹¹ Kawano Dermatology Clinic , Tokyo, Japan.
¹² Department of Dermatology, Seirei Mikatahara General Hospital , Shizuoka, Japan.
¹³ Hasegawa Dermatology Clinic , Fukushima, Japan.
¹⁴ Furukawa Dermatology Clinic , Fukushima, Japan.
¹⁵ Division of Dermatology, Saitama Citizens Medical Center , Saitama, Japan.
¹⁶ Isonokami Dermatological Clinic , Osaka, Japan.
¹⁷ Fujita Dermatological Clinic , Niigata, Japan.

Abstract

USA300 is an MRSA clone producing PVL, a toxin associated with SSTIs. ΨUSA300 is a USA300 variant recently identified in Japan by Takadama et al. (15). Here, we found that the prevalence rate of PVL-positive MRSA in S. aureus was elevated in the Japanese community, and ΨUSA300 accounted for most of them. ΨUSA300 strains have been isolated from several areas in Japan and were associated with deep-seated SSTIs. This study highlighted the emerging threat posed by ΨUSA300 in Japan.

Keywords: Panton–Valentine leukocidin; USA300; methicillin-resistant Staphylococcus aureus; ΨUSA300.

MeSH terms

Exotoxins / genetics
Humans
Japan / epidemiology
Methicillin-Resistant Staphylococcus aureus* / genetics
Prevalence
Staphylococcal Infections* / epidemiology
Staphylococcus aureus / genetics

Substances

Panton-Valentine leukocidin
Exotoxins

Abstract

MeSH terms

Substances

Grants and funding