Natural hosts and animal models for Rift Valley fever phlebovirus

Yuqing Xu; Xiao Wang; Lu Jiang; Yixuan Zhou; Yihan Liu; Fei Wang; Leiliang Zhang

doi:10.3389/fvets.2023.1258172

Natural hosts and animal models for Rift Valley fever phlebovirus

Front Vet Sci. 2023 Oct 19:10:1258172. doi: 10.3389/fvets.2023.1258172. eCollection 2023.

Authors

Yuqing Xu^{1

2

3}, Xiao Wang^{2

3}, Lu Jiang^{2

3}, Yixuan Zhou^{2

3}, Yihan Liu^{2

3}, Fei Wang^{2

4}, Leiliang Zhang^{1

2

3}

Affiliations

¹ Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.
² Medical Science and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
³ Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
⁴ School of Laboratory Animal and Shandong Laboratory Animal Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Abstract

Rift Valley fever phlebovirus (RVFV) is a zoonotic mosquito-transmitted arbovirus, presenting a serious threat to humans and animals. Susceptible hosts are of great significance for the prevention of RVFV. Appropriate animal models are helpful to better understand the onset and development of diseases, as well as the control measures and vaccine research. This review focuses on the role of animal hosts in the maintenance of the virus, and summarizes the host range of RVFV. We list some common animal models in the process of RVFV research, which would provide some important insights into the prevention and treatment of RVFV, as well as the study of Rift Valley fever (RVF) pathogenesis and vaccines.

Keywords: RVF; RVFV; animal model; natural host; zoonotic.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from National Natural Science Foundation of China (82272306 and 82072270), College Students innovation and entrepreneurship training program of Shandong Province (S202310439074), Taishan Scholars Program (tstp20221142), and Academic Promotion Programme of Shandong First Medical University (2019LJ001).