Genetic background influences pig responses to porcine reproductive and respiratory syndrome virus

Yangli Pei; Chenghong Lin; Hua Li; Zheng Feng

doi:10.3389/fvets.2023.1289570

Genetic background influences pig responses to porcine reproductive and respiratory syndrome virus

Front Vet Sci. 2023 Oct 20:10:1289570. doi: 10.3389/fvets.2023.1289570. eCollection 2023.

Authors

Yangli Pei¹, Chenghong Lin¹, Hua Li¹, Zheng Feng¹

Affiliation

¹ Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes, School of Life Science and Engineering, Foshan University, Foshan, China.

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious and economically significant virus that causes respiratory and reproductive diseases in pigs. It results in reduced productivity and increased mortality in pigs, causing substantial economic losses in the industry. Understanding the factors affecting pig responses to PRRSV is crucial to develop effective control strategies. Genetic background has emerged as a significant determinant of susceptibility and resistance to PRRSV in pigs. This review provides an overview of the basic infection process of PRRSV in pigs, associated symptoms, underlying immune mechanisms, and roles of noncoding RNA and alternative splicing in PRRSV infection. Moreover, it emphasized breed-specific variations in these aspects that may have implications for individual treatment options.

Keywords: PRRSV; PRRSV receptors; acquired immunity; genetic backgrounds; innate immunity; pig breeds; porcine reproductive and respiratory syndrome.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the Guangdong Basic and Applied Basic Research Foundation (2020B1515120016), Key Technologies R&D Program of Guangdong Province (2022B0202090001).