Prevalence and influencing factors of abnormal carotid artery intima-media thickness in Henan Province in China

Tingting Yang; Yating Wang; Xiaoke Zhang; Siyun Xiang; Jing Wen; Wen Wang; Ke Guan; Weixiang Wang; Yang Yang; Liuwei Hao; Yongchun Chen

doi:10.3389/fendo.2023.1266207

Prevalence and influencing factors of abnormal carotid artery intima-media thickness in Henan Province in China

Front Endocrinol (Lausanne). 2023 Oct 20:14:1266207. doi: 10.3389/fendo.2023.1266207. eCollection 2023.

Authors

Tingting Yang¹, Yating Wang², Xiaoke Zhang³, Siyun Xiang¹, Jing Wen¹, Wen Wang¹, Ke Guan¹, Weixiang Wang¹, Yang Yang¹, Liuwei Hao⁴, Yongchun Chen¹

Affiliations

¹ Department of Nutrition, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China.
² Department of Ultrasound, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China.
³ Department of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁴ Department of Health Management, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China.

Abstract

Background: Carotid intima-media thickness (CIMT) has been shown to be a valuable predictor of cardiovascular diseases (CVDs). The aim of this study was to investigate the influencing factors of CIMT among adults in Central China.

Methods: A total of 2,578 participants who underwent physical examination in Henan Provincial People's Hospital between January 2018 and July 2018 were enrolled. The respondents were divided into two subgroups according to their CIMT value (CIMT ≥1.0 mm group and CIMT <1.0 mm group). Variables considered were age, gender, total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) triglycerides, fasting blood glucose, and uric acid levels, as well as hypertension, diabetes, body mass index (BMI), waist-to-hip ratio, body fat percentage, and visceral fat area (VFA). Logistic regression analysis was performed to explore the potential factors influencing CIMT.

Results: The proportion of CIMT ≥1.0 mm among the physical examination population was 27.42% (707/2 578). The analysis of the two groups revealed significant differences in age, sex, hypertension, diabetes, total cholesterol, and HDL cholesterol. In the logistic regression analysis, age (OR=1.071, 95%CI=1.062-1.080), male sex (OR=2.012, 95%CI=1.251-2.238), hypertension (OR=1.337, 95%CI=1.031-1.735), diabetes (OR=1.535, 95%CI=1.045-2.255), HDL cholesterol (OR=0.540, 95%CI=0.366-0.796), and LDL cholesterol (OR=1.336, 95%CI=1.154-1.544) were significantly associated with abnormal CIMT.

Conclusion: Early screening should be carried out among men, the older adults, and those with hypertension, diabetes, and dyslipidemia.

Keywords: CIMT; China; cardiovascular risk; influencing factors; prevalence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carotid Arteries / diagnostic imaging
Carotid Intima-Media Thickness
Cholesterol, HDL
Diabetes Mellitus*
Humans
Hypertension* / epidemiology
Male
Prevalence
Risk Factors
Triglycerides

Substances

Cholesterol, HDL
Triglycerides

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Henan Medical Education Research Project (Wjlx2022015). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.