Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma

Bai Ding; Yinghui Song; Sulai Liu; Chuang Peng; Yujing Zhang

doi:10.7150/jca.86967

Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma

J Cancer. 2023 Sep 25;14(17):3203-3213. doi: 10.7150/jca.86967. eCollection 2023.

Authors

Bai Ding¹, Yinghui Song², Sulai Liu^{1

2}, Chuang Peng¹, Yujing Zhang^{2

3}

Affiliations

¹ Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005 Hunan Province, China.
² Central Laboratory of Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, 410015, China.
³ Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.

Abstract

Cholangiocarcinoma (CCA) is the most recurrent malignant tumor found in the biliary system. It originates from the bile duct epithelial cells characterized by easy metastasis, high intermittent rate, and poor prognosis. Acetaldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, the levels of which are particularly elevated in various of malignant tumors. Additionally, the increased ALDH1 levels are closely related to the degree and prognosis of malignant tumors. This study reviewed the mechanisms underlying the changes in ALDH1 levels in CCA.

Keywords: ALDH1; Cholangiocarcinoma; prognosis.

Publication types

Review