Review on Molecular Mechanism of Hypertensive Nephropathy

Curr Pharm Des. 2023;29(32):2568-2578. doi: 10.2174/0113816128266582231031111516.

Abstract

Hypertension, a prevalent chronic ailment, has the potential to impair kidney function, and thereby resulting in hypertensive nephropathy. The escalating incidence of hypertensive nephropathy attributed to the aging population in urban areas, has emerged as a prominent cause of end-stage renal disease. Nevertheless, the intricate pathogenesis of hypertensive nephropathy poses considerable obstacles in terms of precise clinical diagnosis and treatment. This paper aims to consolidate the research findings on the pathogenesis of hypertensive nephropathy by focusing on the perspective of molecular biology.

Keywords: Hypertension; bioinformatic analysis; gene mutation; gene polymorphism; molecular biology.; nephropathy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Humans
  • Hypertension* / complications
  • Hypertension* / drug therapy
  • Hypertension, Renal* / complications
  • Hypertension, Renal* / drug therapy
  • Hypertension, Renal* / genetics
  • Kidney Failure, Chronic*
  • Nephritis* / complications

Supplementary concepts

  • Hypertensive Nephropathy