1 Department of Pharmacy and Critical Care, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: ivan.kemp@uhs.nhs.uk.
2 Department of Pharmacy and Critical Care, University Hospital Southampton NHS Foundation Trust, Southampton, UK; School of Medicine, University of Southampton, National Institute of Health and Care Research (NIHR), Southampton Biomedical Research Centre, Perioperative and Critical Care Theme, and NIHR Wessex Applied Research Collaborative, Southampton, UK; Institute of Pharmaceutical Sciences, School of Cancer and Pharmacy, King's College, London, UK.