Unveiling the relationship between gut microbiota and heart failure: Recent understandings and insights

Curr Probl Cardiol. 2024 Jan;49(1 Pt C):102179. doi: 10.1016/j.cpcardiol.2023.102179. Epub 2023 Nov 3.

Abstract

Gut microbiota, which comprises a broad range of bacteria inhabiting the human intestines, plays a crucial role in establishing a mutually beneficial relationship with the host body. Dysbiosis refers to the perturbations in the composition or functioning of the microbial community, which can result in a shift from a balanced microbiota to an impaired state. This alteration has the potential to contribute to the development of chronic systemic inflammation. Heart failure (HF) is a largely prevalent clinical condition that has been demonstrated to have variations in the gut microbiome, indicating a potential active involvement in the pathogenesis and advancement of the disease. The exploration of the complex interplay between the gut microbiome and HF presents a potential avenue for the discovery of innovative biomarkers, preventive measures, and therapeutic targets. This review aims to investigate the impact of gut bacteria on HF.

Keywords: Cardiovascular disease; Dysbiosis; Gut microbiota; Heart failure.

Publication types

  • Review

MeSH terms

  • Dysbiosis / complications
  • Dysbiosis / microbiology
  • Gastrointestinal Microbiome*
  • Heart Failure* / therapy
  • Humans
  • Inflammation
  • Microbiota*