Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression

B Rivalta; E Attardi; C Cifaldi; V Rosti; L Pacillo; H Hajrullaj; S Di Cesare; D Amodio; M Algeri; M Luciani; F Barzaghi; A Finocchi; G Di Matteo; A Aiuti; F Locatelli; M T Voso; G Palumbo; C Cancrini

doi:10.1111/bjh.19150

Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression

Br J Haematol. 2024 Jan;204(1):e6-e10. doi: 10.1111/bjh.19150. Epub 2023 Nov 3.

Authors

B Rivalta^{1

2}, E Attardi^{2

3}, C Cifaldi¹, V Rosti⁴, L Pacillo^{1

2}, H Hajrullaj^{2

3}, S Di Cesare^{1

5}, D Amodio^{1

5}, M Algeri⁶, M Luciani⁶, F Barzaghi⁷, A Finocchi^{1

5}, G Di Matteo^{1

5}, A Aiuti^{7

8}, F Locatelli^{6

9}, M T Voso³, G Palumbo^{5

6}, C Cancrini^{1

5}

Affiliations

¹ Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy.
² PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy.
³ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
⁴ Center for the Study of Myelofibrosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
⁵ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁶ Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy.
⁷ Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁸ San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁹ Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.

PMID: 37921255
DOI: 10.1111/bjh.19150

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Follow-Up Studies
GTP Phosphohydrolases / genetics
Humans
Lymphoproliferative Disorders*
Membrane Proteins / genetics
Mutation
Primary Immunodeficiency Diseases*
Proto-Oncogene Proteins B-raf / genetics

Substances

GTP Phosphohydrolases
Membrane Proteins
NRAS protein, human
Proto-Oncogene Proteins B-raf

Publication types

MeSH terms

Substances

Grants and funding