Fluoride exposure and prevalence of osteochondroma in drinking water Endemic fluorosis areas of Heilongjiang Province, China: a cross-sectional study

Yongzheng Ma; Yang Liu; Xiaona Liu; Mang Li; Jing Cui; Zhizhong Guan; Junrui Pei; Yanhui Gao

doi:10.1080/09603123.2023.2277336

Fluoride exposure and prevalence of osteochondroma in drinking water Endemic fluorosis areas of Heilongjiang Province, China: a cross-sectional study

Int J Environ Health Res. 2023 Nov 3:1-14. doi: 10.1080/09603123.2023.2277336. Online ahead of print.

Authors

Yongzheng Ma^{1

2

3}, Yang Liu^{1

2

3}, Xiaona Liu^{1

2

3}, Mang Li^{1

2

3}, Jing Cui^{1

2

3}, Zhizhong Guan⁴, Junrui Pei^{1

2

3}, Yanhui Gao^{1

2

3}

Affiliations

¹ Key Laboratory of Etiology and Epidemiology, National Health Commission & Education Bureau of Heilongjiang Province (23618504), Harbin Medical University, Harbin, Heilongjiang Province, China.
² Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin, Heilongjiang Province, China.
³ Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province, China.
⁴ Department of Pathology and Key Lab of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou Province, China.

PMID: 37921081
DOI: 10.1080/09603123.2023.2277336

Abstract

To investigate the relationship between fluoride exposure and Osteochondroma (OC) prevalence, a cross-sectional study was conducted in drinking water endemic fluorosis areas of Heilongjiang Province, China. Our study first reported that the prevalence of OC was 2.3% in drinking water endemic fluorosis areas of Heilongjiang Province, China, and no difference in gender. Logistic regression analysis found that compared to 1^st quartile participants, the prevalence of OC was 73% lower in the 2^nd quartile participants of WF (Water fluoride), and 3.4 times higher among the 2^nd quartile UF (Urinary fluoride) participants. Our study suggests that 0.259-0.420 mg/L of WF may be considered an appropriate level for reducing OC prevalence, while UF (≥0.750 mg/L) could slightly increase the prevalence of OC. In summary, the link between fluoride and OC prevalence is complicated and needs to be further investigated in a cohort population.

Keywords: Fluoride; cross-sectional study; exostosis; fluorosis; osteochondroma (OC).