Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment

Yilun Wu; Min Cheng; Yi Jiang; Xin Zhang; Jiaxiang Li; Yishen Zhu; Qingqiang Yao

doi:10.1016/j.bioactmat.2023.10.008

Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment

Bioact Mater. 2023 Oct 22:32:385-399. doi: 10.1016/j.bioactmat.2023.10.008. eCollection 2024 Feb.

Authors

Yilun Wu¹, Min Cheng¹, Yi Jiang¹, Xin Zhang², Jiaxiang Li², Yishen Zhu¹, Qingqiang Yao^{1

2}

Affiliations

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
² Department of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Abstract

Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in the body presents an opportunity to target calcium homeostasis as a novel strategies for cancer treatment, with specific advantages in osteosarcoma therapy. In this comprehensive review, we retrospect the calcium biology intersected with cancer progression, highlight the unveiling features of calcium-based biomaterials in regulating both bone homeostasis and cancer development. We also provide an overview of recent breakthroughs in cancer therapy that leverage calcium biomaterials, showcasing their potential to serve as versatile, customizable platforms for osteosarcoma treatment and as reservoirs for supporting bone reconstruction.

Publication types

Review