Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases

Junren Chen; Kexin Zhong; Siqi Qin; Yiqi Jing; Shengmeng Liu; Dan Li; Cheng Peng

doi:10.3389/fphar.2023.1265960

Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases

Front Pharmacol. 2023 Oct 18:14:1265960. doi: 10.3389/fphar.2023.1265960. eCollection 2023.

Authors

Junren Chen^#¹, Kexin Zhong^#¹, Siqi Qin¹, Yiqi Jing¹, Shengmeng Liu¹, Dan Li¹, Cheng Peng¹

Affiliation

¹ State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

^# Contributed equally.

Abstract

Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from a variety of familiar edible plants, such as the seeds of green tea, Morus alba L., and Cuscuta chinensis. It is noteworthy that AG has a wide range of pharmacological activities and possesses therapeutic effects against a variety of diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory diseases, and reproductive system diseases. This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy.

Keywords: Astragalin; diseases; molecular mechanisms; natural source; pharmacological activities.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (U19A2010 and 81891012), Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No ZYYCXTD-D-202209), and Sichuan Science and Technology program (2023NSFSC1537). Sichuan Traditional Chinese Medicine science and technology Industry innovation team: multidimensional evaluation of characteristic traditional Chinese medicine resources and product development innovation team (2022C001).