Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics

Young Min Park; De-Chen Lin

doi:10.1038/s41467-023-42960-6

Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics

Nat Commun. 2023 Nov 2;14(1):7017. doi: 10.1038/s41467-023-42960-6.

Authors

Young Min Park^{1

2}, De-Chen Lin³

Affiliations

¹ Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
² Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
³ Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. dechenli@usc.edu.

Abstract

Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical breakthrough paves the way for the development of precision diagnostic methods and targeted therapies.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Biology
Gene Expression Profiling
Humans
Neoplasms* / genetics
Transcriptome*

Grants and funding

R37 CA237022/CA/NCI NIH HHS/United States