Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer

Yi-Chao Huang; Min-Yi Sung; Tsung-Kun Lin; Chan-Yen Kuo; Yi-Chiung Hsu

doi:10.1016/j.jfma.2023.10.009

Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer

J Formos Med Assoc. 2023 Oct 31:S0929-6646(23)00409-6. doi: 10.1016/j.jfma.2023.10.009. Online ahead of print.

Authors

Yi-Chao Huang¹, Min-Yi Sung², Tsung-Kun Lin³, Chan-Yen Kuo⁴, Yi-Chiung Hsu⁵

Affiliations

¹ Health Services Training Center HSTC, National Defense Medical Center, Taipei, Taiwan; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
² Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
³ School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; Pharmaceutical Management Division, Medical Affairs Bureau, Ministry of National Defense, Taiwan.
⁴ Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
⁵ Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan; Center for Astronautical Physics and Engineering, National Central University, Taoyuan, Taiwan. Electronic address: syic@ncu.edu.tw.

PMID: 37919197
DOI: 10.1016/j.jfma.2023.10.009

Abstract

Oral cancer is a prevalent global issue, with oral squamous cell carcinoma constituting the majority of cases. Standard treatments like surgery, radiotherapy, and chemotherapy are available but may have adverse effects. Molecular gene therapy, focusing on genetic mutations linked to oral cancer, presents a promising alternative.In this study, we evaluated 27 chemotherapeutic drugs and 63 Chinese herbal medicines for their effectiveness, categorized them by their cellular mechanisms, and identified potential adjuvant therapy candidates for oral cancer. Our findings highlight the impact of natural flavonoids on oral cancer cells, inducing apoptosis, and confirming their potential in molecular genetic analysis. In conclusion, the natural compounds present in Chinese herbal medicine, particularly flavonoids, offer a promising avenue to target specific genetic mutations in oral cancer cells. This approach may reduce the risks associated with oral cancer treatment and pave the way for innovative adjuvant therapies.

Keywords: Adjuvant treatment; Chemotherapy; Chinese herbal medicine; Flavonoid; Oral cancer.

Publication types

Review