Colchicine in atrial fibrillation: are old trees in bloom?

Front Physiol. 2023 Oct 17:14:1260774. doi: 10.3389/fphys.2023.1260774. eCollection 2023.

Abstract

Colchicine is a widely used drug that was originally used to treat gout and rheumatic diseases. In recent years, colchicine has shown high potential in the cardiovascular field. Atrial fibrillation (AF) is a cardiovascular disease with a high incidence. One of the most frequent complications following cardiovascular surgery is postoperative atrial fibrillation (POAF), which affects patient health and disease burden. This article reviews the research status of colchicine in AF and summarizes the relevant progress.

Keywords: NLRP3 inflammasome; atrial fibrillation; colchicine; inflammation; postoperative atrial fibrillation.

Publication types

  • Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the National Natural Science Foundation of China, Grant number 82370319; the National Natural Science Foundation of China, Grant number 82172060; Department of Science and Technology of Sichuan Province, Grant numbers 2022YFS0362 and 2022YFS0363; Post-Doctor Research Project, West China Hospital, Sichuan University, Grant number 2021HXBH070; and Key Laboratory of Emergency and Trauma of Ministry of Education (Hainan Medical University), Grant number KLET-202114.