Association between Kidney Donor Risk Index, kidney graft function and histological changes in early post-transplant graft biopsy

Natalia Słabiak-Błaż; Agata Kujawa-Szewieczek; Aureliusz Kolonko; Joanna Ziółkowska; Henryk Karkoszka; Andrzej Więcek; Grzegorz Piecha

doi:10.1093/ckj/sfad124

Association between Kidney Donor Risk Index, kidney graft function and histological changes in early post-transplant graft biopsy

Clin Kidney J. 2023 Jun 15;16(11):2226-2234. doi: 10.1093/ckj/sfad124. eCollection 2023 Nov.

Authors

Natalia Słabiak-Błaż¹, Agata Kujawa-Szewieczek¹, Aureliusz Kolonko¹, Joanna Ziółkowska¹, Henryk Karkoszka¹, Andrzej Więcek¹, Grzegorz Piecha¹

Affiliation

¹ Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.

Abstract

Background: Proper assessment of donor organ quality is crucial for optimal kidney allocation and best long-term outcomes. The aim of this study was to analyze the association between the Kidney Donor Risk Index (KDRI) and histological parameters in early post-transplant graft biopsy in a Polish cohort of kidney transplant recipients.

Methods: In 418 consecutive kidney transplant recipients, a histological evaluation of very early [at median 11 (9-13) post-transplant day] protocol core needle biopsy was performed and analyzed according to the Banff classification. Subjects were divided into quartiles of the KDRI value. Kidney graft function, patient and graft survival were also analyzed over a median follow-up period of 44 (26-56) months.

Results: There was a significant trend toward greater intensity of chronic histology changes along the KDRI quartiles (χ² = 20.8; P < .001), including interstitial fibrosis, tubular atrophy, mesangial matrix increase and arteriolar hyalinosis. Stepwise multivariate regression analysis revealed that only higher KDRI value independently increased the severity of chronic graft injury (r_partial = 0.340, P < .001). KDRI values were valuable in the determination of both early and long-term graft function.

Conclusion: The KDRI values correlate with chronic histological changes found in early post-implantation kidney biopsies and can also be helpful in the prediction of graft outcome.

Keywords: Kidney Donor Risk Index; early post-transplant biopsy; graft outcome; kidney allocation; kidney transplantation.