A decade in focus: mixed germ cell tumors with choriocarcinoma components

Abdullah Al-Khayal; Yasser Noureldin; Mohammad Alghafees; Areez Shafqat; Belal Nedal Sabbah; Asem H Elhossiny; Mohamad Bakir; Mohammed Ali Omar; Tarek Ziad Arabi; Saleha Abdul Rab; Bader Alsaikhan; Reema Aldhalaan; Muhannad Alquirnas; Khalid Alrabeeah

doi:10.1097/MS9.0000000000001314

A decade in focus: mixed germ cell tumors with choriocarcinoma components

Ann Med Surg (Lond). 2023 Sep 20;85(11):5355-5358. doi: 10.1097/MS9.0000000000001314. eCollection 2023 Nov.

Authors

Abdullah Al-Khayal^{1

2

3}, Yasser Noureldin¹, Mohammad Alghafees², Areez Shafqat⁴, Belal Nedal Sabbah⁴, Asem H Elhossiny⁴, Mohamad Bakir⁴, Mohammed Ali Omar⁴, Tarek Ziad Arabi⁴, Saleha Abdul Rab⁴, Bader Alsaikhan^{1

2

3}, Reema Aldhalaan⁴, Muhannad Alquirnas², Khalid Alrabeeah^{1

2

3}

Affiliations

¹ Department of Urology, King Abdulaziz Medical City.
² College of Medicine, King Saud bin Abdulaziz University for Health Sciences.
³ King Abdullah International Medical Research Center.
⁴ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Abstract

Introduction: This 10-year registry review aimed to investigate the clinical behaviour and outcomes of mixed germ cell tumours with choriocarcinoma components, a rare and aggressive subtype of testicular cancer, in Saudi Arabia. The study explores the demographic characteristics of affected patients, tumour profiles, and the mortality rate associated with this malignancy.

Methods: Utilizing data from the Saudi Cancer Registry, the authors identified 33 cases of mixed germ cell tumours with choriocarcinoma components among 1001 testicular cancer cases recorded between 2008 and 2017. Demographic information, including age, marital status, region of residency, year of diagnosis, and 10-year survival status, were collected. Tumour factors, such as the basis of diagnosis, origin site, behaviour, grade, extension, and laterality, were also analyzed.

Results: The majority of cases (78.8%) occurred in the young age group (18-45 years), and most tumours (97%) originated in normally descended testes. Grade IV (undifferentiated anaplastic) tumours and distant metastasis were present in 45.5% of patients. All cases exhibited malignant tumour behaviour. The overall mortality rate was 15%, with a mean time from diagnosis to death of 7.72 months (range: 0.5-21.5 months).

Conclusion: Mixed germ cell tumours with choriocarcinoma components are rare and tend to affect younger populations. These tumours demonstrate aggressive clinical behaviour, with a significant proportion presenting with high-grade lesions and metastasis at diagnosis. The observed mortality rate underscores the poor prognosis associated with this malignancy. Our study provides essential insights into the clinical characteristics of this rare tumour subtype in the Saudi Arabian population, emphasizing the need for further research to identify prognostic factors and optimize management strategies for affected patients.

Keywords: Saudi Arabia; mixed germ cell tumours; rare tumours; testicular cancer; tumour registries.