Lewis acid-promoted direct synthesis of isoxazole derivatives

Dengxu Qiu; Chenhui Jiang; Pan Gao; Yu Yuan

doi:10.3762/bjoc.19.113

Lewis acid-promoted direct synthesis of isoxazole derivatives

Beilstein J Org Chem. 2023 Oct 16:19:1562-1567. doi: 10.3762/bjoc.19.113. eCollection 2023.

Authors

Dengxu Qiu¹, Chenhui Jiang¹, Pan Gao¹, Yu Yuan¹

Affiliation

¹ College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

Abstract

Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.

Keywords: Lewis acid; aluminum trichloride; isoxazole derivatives; sodium nitrite; transition metals.

Grants and funding

We are grateful for the financial support from the China Postdoctoral Science Foundation (2018T110533), the Natural Science Foundation of Jiangsu Province (BK20161328, BK20210789), and the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions, and the Priority Academic Program Development of Jiangsu Higher Education Institutions.