Role of stress granules in tumorigenesis and cancer therapy

Tiansheng Li; Zhaoyang Zeng; Chunmei Fan; Wei Xiong

doi:10.1016/j.bbcan.2023.189006

Role of stress granules in tumorigenesis and cancer therapy

Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):189006. doi: 10.1016/j.bbcan.2023.189006. Epub 2023 Oct 31.

Authors

Tiansheng Li¹, Zhaoyang Zeng¹, Chunmei Fan², Wei Xiong³

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
² NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China. Electronic address: fanchunmei@csu.edu.cn.
³ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. Electronic address: xiongwei@csu.edu.cn.

PMID: 37913942
DOI: 10.1016/j.bbcan.2023.189006

Abstract

Stress granules (SGs) are membrane-less organelles that cell forms via liquid-liquid phase separation (LLPS) under stress conditions such as oxidative stress, ER stress, heat shock and hypoxia. SG assembly is a stress-responsive mechanism by regulating gene expression and cellular signaling pathways. Cancer cells face various stress conditions in tumor microenvironment during tumorigenesis, while SGs contribute to hallmarks of cancer including proliferation, invasion, migration, avoiding apoptosis, metabolism reprogramming and immune evasion. Here, we review the connection between SGs and cancer development, the limitation of SGs on current cancer therapy and promising cancer therapeutic strategies targeting SGs in the future.

Keywords: Cancer; Cancer therapy; Liquid-liquid phase separation; Stress granule.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis / metabolism
Cytoplasmic Granules* / metabolism
Humans
Oxidative Stress
Stress Granules
Stress, Physiological*
Tumor Microenvironment