Environmental Conditions as Determinants of Kidney Stone Formation

ACS Appl Bio Mater. 2023 Nov 20;6(11):5030-5036. doi: 10.1021/acsabm.3c00722. Epub 2023 Nov 1.

Abstract

Urolithiasis is a disease characterized by the presence of stones in the urinary tract, whether in the kidneys, ureters, or bladder. Its origin is multiple, and causes can be cited as hereditary, environmental, dietary, anatomical, metabolic, or infectious factors. A kidney stone is a biomaterial that originates inside the urinary tract, following the principles of crystalline growth, and in most cases, it cannot be eliminated naturally. In this work, 40 calculi from the Don Benito, Badajoz University Hospital are studied and compared with those collected in Madrid to establish differences between both populations with the same pathology and located in very different geographical areas. Analysis by cathodoluminescence offers information on the low crystallinity of the phases and their hydration states, as well as the importance of the bonds with the Ca cation in all of the structures, which, in turn, is related to environmental and social factors of different population groups such as a high intake of proteins, medications, bacterial factors, or possible contamination with greenhouse gases, among other factors.

Keywords: Don Benito (Badajoz); Madrid; Spain; kidney stone; oxalate; rural/urban area; struvite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials
  • Crystallization
  • Humans
  • Kidney Calculi* / epidemiology
  • Kidney Calculi* / etiology

Substances

  • Biocompatible Materials