MST1/2 in inflammation and immunity

Cell Adh Migr. 2023 Dec;17(1):1-15. doi: 10.1080/19336918.2023.2276616. Epub 2023 Nov 1.

Abstract

The mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity.

Keywords: Immunity; inflammation; pathways; the mammalian Sterile 20-like 1; the mammalian Sterile 20-like 2.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Humans
  • Inflammation* / pathology
  • Mammals / metabolism
  • Mitochondria / metabolism
  • Mitochondrial Proteins / metabolism
  • Mitochondrial Proteins / pharmacology
  • NF-kappa B / metabolism
  • Peptide Elongation Factors / metabolism
  • Peptide Elongation Factors / pharmacology
  • Protein Serine-Threonine Kinases* / metabolism
  • Tumor Necrosis Factor-alpha / metabolism
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Protein Serine-Threonine Kinases
  • Tumor Necrosis Factor-alpha
  • NF-kappa B
  • MIEF1 protein, human
  • Peptide Elongation Factors
  • Mitochondrial Proteins

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 82160007), the Yunnan Provincial Science and Technology Department (No. 2019FE001(-58), 202201AY070001(-074)), Yunnan Province young and middle-aged academic and technical leaders reserve talent project (No. 202305AC160017), 535 Talent Project of First Affiliated Hospital of Kunming Medical University (No. 2023535D12), and Student Innovation Fund project of Kunming Medical University (Nos. 2022JXD212, 2022JXD227).