Photoredox Metal-Free Synthesis of Unnatural β-Silyl-α-Amino Acids via Hydrosilylation

Abstract

An efficient, practical and metal-free methodology for the synthesis of β-silyl-α-amino acid motifs via photoredox and hydrogen atom transfer (HAT) process is described. This protocol enables the direct hydrosilylation of dehydroalanine derivatives and tolerates a wide array of functional groups and synthetic handles, leading to valuable β-silyl-α-amino acids with moderate to good yields.

Keywords: hydrosilylation; metal-free; photoredox; radical reactions; β-silyl-α-amino acid.