Functional Tissue Units in the Human Reference Atlas

Supriya Bidanta; Katy Börner; Bruce W Herr 2nd; Marcell Nagy; Katherine S Gustilo; Rachel Bajema; Libby Maier; Roland Molontay; Griffin Weber

doi:10.1101/2023.10.16.562593

Functional Tissue Units in the Human Reference Atlas

bioRxiv [Preprint]. 2023 Oct 26:2023.10.16.562593. doi: 10.1101/2023.10.16.562593.

Authors

Supriya Bidanta¹, Katy Börner¹, Bruce W Herr 2nd¹, Marcell Nagy², Katherine S Gustilo¹, Rachel Bajema¹, Libby Maier¹, Roland Molontay², Griffin Weber³

Affiliations

¹ Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN 47408, USA.
² Department of Stochastics, Institute of Mathematics, Budapest University of Technology and Economics, Muegyetem rkp. 3., H-1111 Budapest, Hungary.
³ Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding and modeling the healthy physiological function of the organ and changes during disease states. In this first comprehensive catalog of FTUs, we document the definition, physical dimensions, vasculature, and cellular composition of 22 anatomically correct, nested functional tissue units (FTUs) in 10 healthy human organs. The catalog includes datasets, illustrations, an interactive online FTU explorer, and a large printable poster. All data and code are freely available. This is part of a larger ongoing international effort to construct a Human Reference Atlas (HRA) of all cells in the human body.

Publication types

Preprint

Abstract

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