Sepsis is an uncontrolled host response to infection, resulting in a clinical syndrome involving multiple organ dysfunctions. Cardiac damage is the most common organ damage in sepsis. Uncontrolled inflammatory response is an important mechanism in the pathogenesis of septic cardiomyopathy (SCM). NLRP3 inflammasome promotes inflammatory response by controlling the activation of caspase-1 and the release of pro-inflammatory cytokines interleukin IL-1β and IL-18. The role of NLRP3 inflammasome has received increasing attention, but its activation mechanism and regulation of inflammation in SCM remain to be investigated.
Keywords: activation mechanism; cytokines; inflammatory response; nucleotide-binding oligomerized structural domain-like receptor protein 3 inflammasome; septic cardiomyopathy.
© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.