Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

J Vis Exp. 2023 Oct 13:(200). doi: 10.3791/65786.

Abstract

For patients with early multiple pulmonary nodules, it is essential, from a diagnostic perspective, to determine the spatial distribution, size, location, and relationship with surrounding lung tissue of these nodules throughout the entire lung. This is crucial for identifying the primary lesion and developing more scientifically grounded treatment plans for doctors. However, pattern recognition methods based on machine vision are susceptible to false positives and false negatives and, therefore, cannot fully meet clinical demands in this regard. Visualization methods based on maximum intensity projection (MIP) can better illustrate local and individual pulmonary nodules but lack a macroscopic and holistic description of the distribution and spatial features of multiple pulmonary nodules. Therefore, this study proposes a whole-lung 3D reconstruction method. It extracts the 3D contour of the lung using medical image processing technology against the background of the entire lung and performs 3D reconstruction of the lung, pulmonary artery, and multiple pulmonary nodules in 3D space. This method can comprehensively depict the spatial distribution and radiological features of multiple nodules throughout the entire lung, providing a simple and convenient means of evaluating the diagnosis and prognosis of multiple pulmonary nodules.

Publication types

  • Video-Audio Media
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Imaging, Three-Dimensional / methods
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Neoplasms* / pathology
  • Multiple Pulmonary Nodules* / pathology
  • Solitary Pulmonary Nodule* / diagnostic imaging
  • Solitary Pulmonary Nodule* / pathology
  • Tomography, X-Ray Computed / methods