Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

Shaleniprieya Muniandy; Ling Ling Few; Boon Yin Khoo; Siti Asma' Hassan; Get Bee Yvonne-Τee; Wei Cun See Too

doi:10.3892/br.2023.1673

Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

Biomed Rep. 2023 Oct 10;19(6):91. doi: 10.3892/br.2023.1673. eCollection 2023 Dec.

Authors

Shaleniprieya Muniandy¹, Ling Ling Few¹, Boon Yin Khoo², Siti Asma' Hassan³, Get Bee Yvonne-Τee¹, Wei Cun See Too¹

Affiliations

¹ School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
² Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia.
³ School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Abstract

MicroRNA (miR)-367 has a wide range of functions in gene regulation and as such plays a critical role in cell proliferation, differentiation and development, making it an essential molecule in various physiological processes. miR-367 belongs to the miR-302/367 cluster and is located in the intronic region of human chromosome 4 on the 4q25 locus. Dysregulation of miR-367 is associated with various disease conditions, including cancer, inflammation and cardiac conditions. Moreover, miR-367 has shown promise both as a tumor suppressor and a potential diagnostic biomarker for breast, gastric and prostate cancer. The elucidation of the essential role of miR-367 in inflammation, development and cardiac diseases emphasizes its versatility in regulating various physiological processes beyond cancer biology. However, further research is necessary to fully understand the complex regulatory mechanisms involving miR-367 in different physiological and pathological contexts. In conclusion, the versatility and significance of miR-367 makes it a promising candidate for further study and in the development of new diagnostic and therapeutic strategies.

Keywords: biomarker; cancer biology; miR-367; microRNA; therapeutic target.

Publication types

Review

Grants and funding

Funding: This research was funded by The Malaysia Ministry of Higher Education Fundamental Research Grant Scheme [grant no. FRGS/1/2021/SKK0/USM/02/34 (203/PPSK/6171299)].