Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Dengfeng Lu; Yun Feng; Guangjie Liu; Yayi Yang; Yubo Ren; Zhouqing Chen; Xiaoou Sun; Yixiang Guan; Zhong Wang

doi:10.3389/fnins.2023.1268883

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Front Neurosci. 2023 Oct 12:17:1268883. doi: 10.3389/fnins.2023.1268883. eCollection 2023.

Authors

Dengfeng Lu¹, Yun Feng², Guangjie Liu¹, Yayi Yang², Yubo Ren¹, Zhouqing Chen¹, Xiaoou Sun¹, Yixiang Guan³, Zhong Wang¹

Affiliations

¹ Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
² Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
³ Department of Neurosurgery, Hai'an People's Hospital Affiliated of Nantong University, Nantong, Jiangsu, China.

Abstract

Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.

Keywords: TRAK; acute neurological disorders; dynein; kinesin; miro; myosin.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (No. 81971171 for XS) and the Suzhou Health Talents Training Project (GSWS2019002 for ZW).