[South American Hemorrhagic Fever viruses and the cutting edge of the vaccine and antiviral development]

Meion Lee; Takaaki Koma; Masaharu Iwasaki; Shuzo Urata

doi:10.2222/jsv.72.7

[South American Hemorrhagic Fever viruses and the cutting edge of the vaccine and antiviral development]

Uirusu. 2022;72(1):7-18. doi: 10.2222/jsv.72.7.

[Article in Japanese]

Authors

Meion Lee^{1

2}, Takaaki Koma³, Masaharu Iwasaki⁴, Shuzo Urata^{1

5}

Affiliations

¹ National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University.
² Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University.
³ Department of Microbiology, Graduate School of Medicine, Tokushima University.
⁴ Laboratory of Emerging Viral Diseases, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University.
⁵ Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University.

PMID: 37899233
DOI: 10.2222/jsv.72.7

Abstract

South American Hemorrhagic Fever is caused by the Arenavirus, which belong to the Family Arenaviridae, genus mammarenavirus, infection at South America. South American Hemorrhagic Fever includes 1. Argentinian Hemorrhagic fever caused by Junin virus, 2. Brazilian hemorrhagic fever caused by Sabia virus, 3. Venezuelan Hemorrhagic fever caused by Guanarito virus, 4. Bolivian Hemorrhagic fever caused by Machupo virus, and 5. Unassigned hemorrhagic fever caused by Chapare virus. These viruses are classified in New World (NW) Arenavirus, which is different from Old World Arenavirus (ex. Lassa virus), based on phylogeny, serology, and geographic differences. In this review, the current knowledge of the biology and the development of the vaccines and antivirals of NW Arenaviruses which cause South American Hemorrhagic Fever will be described.

Publication types

English Abstract