Desmoid fibroma simulating malignant breast neoplasm: A case report and literature review

Breast Dis. 2023;42(1):319-323. doi: 10.3233/BD-230028.

Abstract

Introduction: Desmoid fibroma (DF) is a disorder characterized by strong clonal proliferation of myofibroblasts and fibroblasts. We describe a case of DF that mimicked a breast tumor, along with a review of the literature on the clinical manifestation, diagnostic process, and course of therapy for this combative disease.

Case report: A 34-year-old female patient with breast lump at the junction of the upper quadrants of the left breast. After the diagnosis of DF, it was decided to perform a sectorectomy of the left breast associated with post-quadrant reconstruction, with immunohistochemistry and findings compatible with DF.

Discussion: Clinically manifests as a solid mass that is often painless and occasionally adherent to the chest wall. A treatment strategy should be idealized for each patient. Thus, there is the possibility of performing radical surgery for resection and/or radiotherapy, and surgery may be followed by radiotherapy.

Keywords: Breast; desmoid fibroma; neoplasms.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adult
  • Breast Neoplasms* / diagnosis
  • Female
  • Fibroblasts
  • Fibroma* / diagnosis
  • Fibroma* / surgery
  • Fibromatosis, Aggressive* / diagnosis
  • Fibromatosis, Aggressive* / surgery
  • Humans
  • Thoracic Wall*