Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?

Fernando A Munoz; Emily Hawkins Carter; Erika M Edwards; Maggie Jerome; Jonathan S Litt

doi:10.1038/s41372-023-01808-z

Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?

J Perinatol. 2024 Feb;44(2):301-306. doi: 10.1038/s41372-023-01808-z. Epub 2023 Oct 28.

Authors

Fernando A Munoz¹, Emily Hawkins Carter², Erika M Edwards^{3

4

5}, Maggie Jerome⁶, Jonathan S Litt^{7

8

9}

Affiliations

¹ Division of Neonatology, Oregon Health & Science University, Portland, OR, USA. munozf@ohsu.edu.
² Division of Neonatology, Oregon Health & Science University, Portland, OR, USA.
³ Vermont Oxford Network, Burlington, VT, USA.
⁴ College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, USA.
⁵ Robert Larner, MD, College of Medicine, University of Vermont, Burlington, VT, USA.
⁶ Graduate Programs in Human Nutrition, Oregon Health & Science University, Portland, OR, USA.
⁷ Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
⁸ Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
⁹ Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Boston, MA, USA.

PMID: 37898685
DOI: 10.1038/s41372-023-01808-z

Abstract

Objective: Examine the relationship between weight trajectory and 2-year neurodevelopmental outcomes for extremely low birthweight (ELBW) infants with BPD.

Study design: Secondary analysis of infants born from 2010 to 2019. The predictor was BPD severity and the outcome was neurodevelopmental impairment, defined as any Bayley Scales of Infant Development (BSID) III score <70 at 24 months' corrected age. Repeated measures logistic regression was performed.

Results: In total, 5042 infants were included. Faster weight trajectory was significantly associated with a decreased probability of having at least one BSID III score <70 for infants with grade 1-2 BPD (p < 0.0001) and an increased probability of at least one BSID III score <70 for infants with grade 3 BPD (p < 0.009). There was no significant association between weight trajectory and BSID III score <70 for infants with grade 0 BPD.

Conclusion: The association between postnatal weight trajectory and neurodevelopmental outcome in this study differs by BPD severity.

MeSH terms

Body-Weight Trajectory*
Bronchopulmonary Dysplasia*
Child
Humans
Infant
Infant, Extremely Low Birth Weight
Infant, Newborn