Exercise to prevent the negative effects of sleep deprivation: A systematic review and meta-analysis

Ye Zhao; Boya Huang; Yang Yu; Jiage Luan; Shihao Huang; Ye Liu; Huiping Yang; Yifei Chen; Rui Yang; Jing Dong; Haishui Shi

doi:10.1016/j.neubiorev.2023.105433

Exercise to prevent the negative effects of sleep deprivation: A systematic review and meta-analysis

Neurosci Biobehav Rev. 2023 Dec:155:105433. doi: 10.1016/j.neubiorev.2023.105433. Epub 2023 Oct 28.

Authors

Ye Zhao¹, Boya Huang¹, Yang Yu¹, Jiage Luan², Shihao Huang³, Ye Liu¹, Huiping Yang¹, Yifei Chen¹, Rui Yang¹, Jing Dong⁴, Haishui Shi⁵

Affiliations

¹ Neuroscience Research Center, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang 050017, China.
² Nursing School, Hebei Medical University, Shijiazhuang 050017, China.
³ National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China.
⁴ Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan 430000, Hubei, China.
⁵ Neuroscience Research Center, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang 050017, China; Hebei Key laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang 050017, China; Nursing School, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: shihs@hebmu.edu.cn.

PMID: 37898446
DOI: 10.1016/j.neubiorev.2023.105433

Abstract

Ample sleep is an important basis for maintaining health, however with the pace of life accelerating in modern society, more people are using sacrificial sleep to cope with these social changes. Sleep deprivation can have negative effects on cognitive performance and psychosomatic health. It is well known that exercise, as a beneficial intervention strategy for human health, has been increasingly used in the clinic. But it's not clear if it can prevent the negative effects of sleep deprivation. In this meta-analysis, we reviewed 23 articles from PubMed and Web of Science to investigate whether moderate physical exercise can prevent the negative effects of sleep deprivation in rodents. Our findings suggest that exercise can prevent sleep deprivation-induced cognitive impairment and anxiety-like behaviors through multiple pathways. We also discuss possible molecular mechanisms involved in this protective effect, highlighting the potential of exercise as a preventive or therapeutic strategy for sleep deprivation-induced negative effects.

Keywords: Anxiety; Cognitive impairment; Exercise; Psychosomatic health; Sleep deprivation.

Publication types

Meta-Analysis
Systematic Review
Review

MeSH terms

Anxiety
Exercise*
Humans
Sleep
Sleep Deprivation* / complications
Sleep Deprivation* / psychology