Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity

Phytochemistry. 2024 Jan:217:113900. doi: 10.1016/j.phytochem.2023.113900. Epub 2023 Oct 28.

Abstract

A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1-5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC50 value of 2.09 μM.

Keywords: Dichapetalaceae; Dichapetalin-type triterpenoid; Dichapetalum longipetalum; RAW264.7 murine macrophages.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Macrophages
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Plant Extracts / chemistry
  • Triterpenes* / chemistry
  • Triterpenes* / pharmacology

Substances

  • Triterpenes
  • Plant Extracts
  • Anti-Inflammatory Agents