Current status and prospect of ZIF-based materials for breast cancer treatment

Yana Zeng; Donghui Liao; Xiangyang Kong; Qianying Huang; Muyi Zhong; Jianqiang Liu; Alireza Nezamzadeh-Ejhieh; Ying Pan; Hailiang Song

doi:10.1016/j.colsurfb.2023.113612

Current status and prospect of ZIF-based materials for breast cancer treatment

Colloids Surf B Biointerfaces. 2023 Dec:232:113612. doi: 10.1016/j.colsurfb.2023.113612. Epub 2023 Oct 26.

Authors

Yana Zeng¹, Donghui Liao², Xiangyang Kong², Qianying Huang², Muyi Zhong³, Jianqiang Liu¹, Alireza Nezamzadeh-Ejhieh⁴, Ying Pan⁵, Hailiang Song⁶

Affiliations

¹ The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523700, China; Guangdong Provincial Key Laboratory of Research and DD.evelopment of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan 523808, China.
² Guangdong Provincial Key Laboratory of Research and DD.evelopment of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan 523808, China.
³ Breast Department, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong 523059, China. Electronic address: zmyok0769@163.com.
⁴ Chemistry Department, Shahreza Branch, Islamic Azad University, Shahreza 311-86145, Iran.
⁵ The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523700, China; Guangdong Provincial Key Laboratory of Research and DD.evelopment of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan 523808, China. Electronic address: panying@gdmu.edu.cn.
⁶ Department of General Surgery, Dalang Hospital, Dongguan, Guangdong 523770, China. Electronic address: shl_ywb@163.com.

PMID: 37898043
DOI: 10.1016/j.colsurfb.2023.113612

Abstract

Breast cancer, one of the three most life-threatening cancers in modern times, must be explored for treatments with low side effects and practical efficacy. Metal organic framework materials (MOFs) is made by metal ions as the center for point and organic ligands as a bridge connecting a new type of porous nano-materials, among them, the zinc base zeolite imidazole skeleton material series (ZIFs) because of its excellent biocompatibility and pH slow controlled release ability, is widely used in the tumor microenvironment in basic research and achieved remarkable curative effect. Inspired by this, in this review, we focus on the recent research progress on the application of ZIFs in the treatment of breast cancer, mainly studying the structure of ZIFs such as ZIF-8, ZIF-90 and ZIF-67 and their application in novel therapies for breast cancer treatment, such as targeted drug delivery, photothermal therapy, immunotherapy and gene therapy.We will more fully demonstrate the potential of zif in breast cancer treatment, hoping to provide an avenue for exploring breast cancer treatment.

Keywords: Breast, Mechanism; Treatment; ZIF.

Publication types

Review

MeSH terms

Breast Neoplasms* / therapy
Drug Delivery Systems
Female
Humans
Metal-Organic Frameworks* / chemistry
Tumor Microenvironment

Substances

ZIF-90
Metal-Organic Frameworks