Calcium transport and sensing in TRPC channels - New insights into a complex feedback regulation

Jasmin Baron; Klaus Groschner; Oleksandra Tiapko

doi:10.1016/j.ceca.2023.102816

Calcium transport and sensing in TRPC channels - New insights into a complex feedback regulation

Cell Calcium. 2023 Dec:116:102816. doi: 10.1016/j.ceca.2023.102816. Epub 2023 Oct 18.

Authors

Jasmin Baron¹, Klaus Groschner¹, Oleksandra Tiapko²

Affiliations

¹ Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria.
² Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria. Electronic address: oleksandra.tiapko@medunigraz.at.

PMID: 37897981
DOI: 10.1016/j.ceca.2023.102816

Abstract

Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca²⁺ influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory- and recently uncovered structural features, TRPC channels are considered to coordinate Ca²⁺ and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.

Keywords: Ca(2+) sensing; Cellular regulation; Divalent coordination; TRPC channels.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Calcium Channels / metabolism
Calcium* / metabolism
Feedback
Ion Transport
TRPC Cation Channels* / metabolism

Substances

Calcium
TRPC Cation Channels
Calcium Channels